Concise synthesis of the tricyclic core of lycoposerramine S.
نویسندگان
چکیده
The tricyclic core of lycoposerramine S has been synthesised in 10 steps from a symmetrical cyclohexadiene precursor by way of a desymmetrising free-radical cyclisation and iodocyclisation.
منابع مشابه
Studies towards the total synthesis of lycoposerramine A. Synthesis of a model for the tetracyclic core.
Lycoposerramine A (1) is a pentacyclic alkaloid isolated in 2001 by Takayama and co-workers. A concise synthesis of a model compound 8 for the tetracyclic core of this natural product is described. Key steps include the desymmetrising free-radical cyclisation of compound 7 to give compound 18 and spirocyclisation of compound 26 to give compound 8. Earlier approaches using a novel high-yielding ...
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 6 14 شماره
صفحات -
تاریخ انتشار 2008